of the CVProfilor®
Utilizing the physiological phenomena associated with blood
pressure waveform data, Drs. Jay N. Cohn and Stanley M.
Finkelstein, professors at the University of Minnesota
Medical School in Minneapolis, developed in the early 1980’s
a method for determining a measure of elasticity in both
large and small arteries.
The technique involved an
invasive procedure that placed a small catheter connected to
a pressure transducer into the patient’s artery in order to
obtain a blood pressure waveform that could be analyzed
using a modified Windkessel model. This model is a
well-established electrical analog model which describes the
pressure changes during the diastolic phase of the cardiac
cycle in the circulatory system.
The modified Windkessel model
represents the vasculature as consisting of a capacitive
compliance element (C1 - Large Artery Elasticity Index), an
oscillatory or reflective compliance element (C2 - Small
Artery Elasticity Index), an inductance and a resistance,
during the diastolic decay portion of the cardiac cycle.
to the initial studies of Drs. Cohn and Finkelstein, HD
developed a non-invasive approach. This blood pressure
waveform or "pulse contour analysis" method provided an
independent assessment of the elasticity or flexibility of
the large arteries which expand to briefly store blood
ejected by the heart, and of the very small arteries (and
arterioles) which produce oscillations or reflections in
response to the blood pressure waveform generated during
each heart beat. These developments led to the current
technology used today in the CVProfilor®