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Science Behind the Device 


 
Part 1 | Part 2 | Part 3 | Part 4


The following is a small sample of the information and studies that help support the CVProfilor® science and method:

1.  Loss of Elasticity is a Marker for Atherosclerotic Plaque Burden

  • Elasticity measurements can be used for identification of patients with diffuse atherosclerotic processes of the coronary arteries

  • Small Artery Elasticity was found to be an independent predictor of coronary artery status as assessed by angiogram

Syeda, B. et al, Arterial Compliance: A Diagnostic Marker for Atherosclerotic Plaque Burden?, American Journal of Hypertension, 16:356-362, 2003, ( U of Vienna, Austria) Ref: 197
 

2.  Loss of Small Artery Elasticity is Predictive of Cardiovascular Events

  • For every 2-unit decrease in C2-Small Artery Elasticity Index, there is a 50% increase in cardiovascular events (p < .001)

  • Overall accuracy of C2-Small Artery Elasticity in predicting likelihood of cardiac events = 76.8%

  • Occurrence of events as a function of baselinearterial compliance:
    N=419 subjects; 1 to 7 year follow-up
    End points: MI, stroke, TIA, angina, coronary or peripheral revascularization, coronary artery or peripheral bypass graft, death

Grey, E. et.al, Small But Not Large Artery Compliance Predicts Cardiovascular Events, American Journal of Hypertension 16(No. 4), 265-269, 2003, (U of MN) Ref: 172
 

3.  Repeatability of Arterial Elasticity Assessments

  • Healthy subjects from 7 European sites

  • Intra-visit measurements taken 5 minutes apart differed by less than 3%

  • Inter-visit measurements taken 1-5 weeks later differed by less than 4%

  • Conclusion: Measurement of AE is highly reproducible despite the fact that BP and hemodynamic status was not identical

Zimlichman, R. et. al, Determination of Arterial Compliance Using Blood Pressure WaveformAnalysis with the CR-2000 System, American Journal of Hypertension 18 (No.1):65-71, 2005
 

4). Small Artery Elasticity is a Sensitive Marker for Endothelial Dysfunction

Type

Control L-NAME

  P Value

Blood Pressure

112/65 122/75

<0.01

Mean Arterial Pressure

80.2 90.4

<0.001

Pulse Wave Velocity

8.25 8.98

0.04

Brachial Artery Area1

10.8 11.0

NS

Brachial Artery Compliance1

0.0027 0.0049

0.07

Augmentation Index %

48.3 64.6

<0.05

Flow Mediated Vasodilatation

%1 5.29 4.47

0.06

C2 Small Artery Elasticity

2  9.9 6.9

<0.001

Systemic Vascular Resistance

2  1200 1487

<0.001

1 Measured using high-fidelity echo-tracking ultrasound
2 Measured using HD’s CardioVascular Profiling System

Gilani, M et al., Role of nitric oxide deficiency and its detection as a risk factor in prehypertension, Journal of the American Society of Hypertension 1(No. 1), 45-55, 2007; Ref 261
 

5). American Society of Hypertension Emphasizing Need to Go Beyond Blood Pressure

  • 2005 definition of hypertension from ASH:
    – Vascular abnormalities are central to the identification and treatment of hypertension
    – Need to identify where the patient is on the disease continuum to individualize assessment and treatment
    – Need global cardiovascular disease risk assessment, need to go beyond lowering blood pressure

  • 2007 ESH guidelines for treating hypertension now include vascular assessment

Giles, T. et.al, Expanding the Definition and Classification of Hypertension, The Journal of Clinical Hypertension 7 (No. 9):505-512, Ref. 229A